Vielbeachtet, vielzitiert

advanceCOR ist ein forschungsstarkes Unternehmen. Unsere Wissenschaftler publizieren ihre Ergebnisse regelmäßig in renommierten Fachjournalen.

2021

Efficacy and Safety of Revacept, a Novel Lesion-Directed Competitive Antagonist to Platelet Glycoprotein VI, in Patients Undergoing Elective Percutaneous Coronary Intervention for Stable Ischemic Heart Disease TheRandomized, Double-blind, Placebo-Controlled ISAR-PLASTERPhase 2 Trial hier als PDF lesen

Supplemental Online Content
Mayer K, Hein-Rothweiler R, Schüpke S, et al. Efficacy and safety of revacept, a novel lesion-directed competitive antagonist to platelet glycoprotein vi, in patients undergoing elective percutaneous coronary intervention for stable ischemic heart disease: the randomized, double-blind, placebo-controlled ISAR-PLASTER phase 2 trial. JAMA Cardiol. Published online March 31, 2021. doi:10.1001/jamacardio.2021.0475 hier als PDF lesen

2020

Sara Alberti, Qianqian Zhang, Ilaria D’Agostino, Annalisa Bruno, Stefania Tacconelli, Annalisa Contursi, Simone Guarnieri, Melania Dovizio, Lorenza Falcone, Patrizia Ballerini, Götz Münch, Ying Yu & Paola Patrignani. The antiplatelet agent revacept prevents the increase of systemic thromboxane A2 biosynthesis and neointima hyperplasia. nature research Scientific Reports | (2020) 10:21420 – Artikel online lesen oder hier als PDF lesen

Gröschel K, Uphaus T, Loftus I., Poppert H, Diener HC, Zobel J, Münch G. Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Artery Stenosis: Design and Rationale of a Randomized Phase II Clinical Trial. Volume 04, Number 04 of TH Open – Artikel online lesen oder Artikel hier als PDF lesen

2019

Zeibig S, Büttcher M, Goebel S,  Pauli J, Hunger A, Ungerer M, Gawaz M  Münch G. The Scavenger Receptor CD68 Regulates Platelet Mediated Oxidized Low-Density Lipoprotein (oxLDL) Deposition in Atherosclerotic Vessels at an Early Stage of Atherosclerosis in LDLR-/-/ApoBec-/- Mice. Cell Physiol Biochem 2019;52;681-695 – Artikel online lesen oder hier als PDF lesen

Faßbender J, Holthoff HP, Li Z, Ungerer M.  Therapeutic Effects of Short Cyclic and Combined Epitope Peptides in a Long-Term Model of Graves’ Disease and Orbitopathy. THYROID Volume 29, Number 2, 2019 – Artikel hier als PDF lesen

2018

Boivin-Jahns V, Uhland K, Holthoff H-P,Beyersdorf N, Kocoski V, Kerkau T, Münch G, Lohse M. Ungerer M, Jahns R. Cyclopeptide COR-1 to treat beta1-adrenergicreceptor antibody-induced heart failure. PLoS ONE13(8): publ Aug 20, 2018 – Artikel hier als PDF lesen

2017

Holthoff HP, Li Z, Faßbender J, Reimann Adler K, Münch G, Ungerer M, Cyclic Peptides for effective treatment in a long term model of Graves Disease and Orbitopathie in female mice , Endocrinology 158:1-16, 2017 – Artikel als PDF lesen

Mojica Muñoz AK, Jamasbi J, Uhland K, Degen H, Münch G, Ungerer M, Megens R, Weber C, Lorenz R, Brandl R, Siess W. Recombinant GPVI-Fc added to single or dual antiplatelet therapy in vitro prevents plaque-induced platelet thrombus formation. Thromb Haemost. 2017; 117(8):1651-1659 – Artikel online lesen

Degen H, Borst O, Ziegler M, Mojica Munoz AK, Jamasbi J, Walker B, Göbel S, Fassbender J, Adler K, Brandl R, Münch G, Lorenz R, Siess W, Gawaz M, Ungerer M. ADPase CD 39 fused to glycoprotein VI boosts local anti-thrombotic effects at vascular lesions. J Am Heart Ass 2017, 6:e005991; as of July 27, 2017 – Artikel online lesen oder hier als PDF lesen

2016

Ungerer M, Faßbender J, Li Z, Münch G, Holthoff HP.  Review of Mouse Models of Graves’ Disease and Orbitopathy—Novel Treatment by Induction of Tolerance. Clinic Rev Allerg Immunol /2016-016-8562-7 – Artikel als PDF lesen

Baumgartner C,  Brandl J,  Münch G, , Ungerer M. Rabbit models to study atherosclerosis and its complications e Transgenic vascular protein expression in vivo  Progress in Biophysics and Molecular Biology 121 (2016) 131e141 – Artikel online lesen

2015

Kommentiert in: Kleiman NS; Kolandaivelu K. Expanding the Roster : Developing New Inhibitors of Intravascular Thrombosis. J Am Coll Cardiol 2015; 65 (22): 2416 – 2419 – Artikel online lesen

Jamasbi J, Megens RTA, Bianchini M, Münch G, Ungerer M, Faussner A, Sherman S, Walker A, Goyal P, Jung S, Brandl R, Weber C, Lorenz R, Elia N, Farndale J, Siess W. Differential inhibition of human atherosclerotic plaque- induced platelet activation by dimeric GPVI-Fc and anti-GPVI antibodies: functional and imaging studies. J Am Coll Cardiol 2015; 65 (22): 2404-2415 – Artikel online lesen

Holthoff HP, Goebel S,  Li Z, Faßbender J,Reimann A, Zeibig S, Lohse M, Münch G, Ungerer M. Prolonged TSH Receptor A Subunit Immunization of Female Mice Leads to a Long-Term Model of Graves’Disease, Tachycardia, and Cardiac Hypertrophy. Endocrinology, April 2015, 156(4):1577–1589 – Artikel als PDF lesen

2013

Ungerer M, Münch G. Novel antiplatelet drugs in clinical development. Thromb Haemost 2013; 110 – Artikel online lesen

Dovizio M, Maier TH, Alberti S, Di Francesco L, Marcantoni E, Münch G, John C, Suess B, Sgambato A, Steinhilber D, Patrignani P. Pharmacological Inhibition of Platelet-Tumor Cell Cross-Talk Prevents Platelet-Induced Overexpression of Cyclooxygenase-2 in HT29 Human Colon Carcinoma Cells. Mol Pharmacol 84:25–40, July 2013 – Artikel als PDF lesen

Ungerer M, Li ZM, Baumgartner C, Göbel S, Vogelmann J, Holthoff HP, Bültmann A, Gawaz M, Münch G. The GPVI – Fc fusion protein Revacept reduces thrombus formation and improves vascular dysfunction in atherosclerosis without any impact on bleeding times. PLOS ONE 2013; 8(8):e71193 – Artikel online lesen

Göbel S, Li ZM, Vogelmann J, Holthoff HP, Degen H, Hermann DM, Gawaz M, Ungerer M, Münch G. The GPVI-Fc fusion protein Revacept improves cerebral infarct volume and functional outcome in stroke. PLOS ONE 2013, 8(7):e66960 – Artikel online lesen

2010 - 2012

Baumer Y, Leder C, Ziegler M, Schönberger T, Ochmann C, Perk A, Degen H, Schmid-Horch B, Elvers M, Münch G, Ungerer M, Schlosshauer B, Gawaz M. The recombinant bifunctional protein aCD133–GPVI promotes repair of the infarcted myocardium in mice. J Thromb Haemost 2012; 10: 1152–64 – Artikel als PDF lesen

Bültmann A, Li Z, Wagner S, Peluso M, Schönberger T, Weis C, Konrad I, Stellos K, Massberg S, Nieswandt B, Gawaz M, Ungerer M, Münch G. Impact of glycoprotein VI and platelet adhesion on atherosclerosis–a possible role of fibronectin. J Mol Cell Cardiol 2010; 49(3):532-42 – Artikel online lesen

Zeibig S, Li Z, Wagner S, Holthoff HP, Ungerer M, Bültmann A, Uhland K, Vogelmann J, Simmet T, Gawaz M, Münch G. Effect of the oxLDL binding protein Fc-CD68 on plaque extension and vulnerability in atherosclerosis. Circulation Research 2011; 108:695-703 – Artikel online lesen

Ungerer M, Rosport K, Bültmann A, Piechatzek R, Uhland K, Schlieper P, Gawaz M, Münch G. The novel anti-platelet drug Revacept (dimeric GPVI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general haemostasis in humans. Circulation 2011; 123: 1891-1899. – Artikel online lesen

Bültmann A, Li Z, Wagner S, Gawaz M, Ungerer M, Langer H, May A, Münch G. Loss of protease activity of ADAM15 abolishes protective effects on plaque progression in atherosclerosis. Int J Cardiol 152_2011 pp. 382-385 – Artikel als PDF lesen

Holthoff HP, Zeibig S, Jahns-Boivin V, Bauer J, Lohse M, Kääb S, Clauss S, Jahns R, Schlipp A, Münch G, Ungerer M. Detection of  Anti–β1-AR Autoantibodies in Heart Failure by a Cell-Based Competition ELISA. Circulation Research. 2012;111:675–684 – Artikel online lesen oder hier als PDF lesen